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What Religious Liberty?
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The Incredible Ever-Expanding Dead End Proponents of embryonic stem cell research (ESCR) say that adult stem cell research (ASCR) is at a dead end. ESCR is not at a dead end for the simple reason its beginning is dead. There have been zero therapies using ESCs while the dead end ASCR is enjoying absolutely frenetic activity and boasts 65 therapies with more on the way. The list of therapies is far too long to reprint here and so I recommend clicking on the website, http://www.stemcellresearch.org for a complete list. While there you can educate yourselves on the basics of stem cells. Adult stem cells now offer 23 therapies for cancer including brain, ovarian, and breast cancer. There are 14 ASC therapies for auto-immune diseases like multiple sclerosis and Crohn’s disease. ASCs have helped to repair heart damage and been used for corneal regeneration. Three therapies are available for immunodeficiencies. Three more for neural-degenerative diseases/injuries. Ten therapies are available for anemias/blood conditions including sickle cell anemia. ASCs help in wounds/injuries including jawbone replacement and skull bone repair. Finally there are six therapies for metabolic disorders. Transplanted ASCs can improve vision in eyes that have been damaged by retinal disease. This holds great promise for potential treatments for people suffering from macular degeneration, diabetic retinopathy and other retinal diseases. Texas researchers believe they have perfected a way to deliver cancer treatment directly to tumors. While the initial experiments have been done on mice, human trials could begin soon. The researchers used ASCs which move like guided missiles, targeting tumor cells. In a Virginia study ASCs taken from human fat have been used to improve the functioning of damaged hearts. ASCs therapy has been found good for the heart in a study by John Hopkins. Among the many benefits of ASCs is their ready availability, meaning they can be extracted from the patient, no donor is required, and the cells can be simply reproduced if more are needed. Scientists in Vancouver, Canada have isolated stem cells form the breast tissue of mice that can regenerate an entire milk-producing mammary gland. The discovery is a landmark achievement for adult stem cell research because adult stem cells have been purified from an adult tissue other than bone marrow or blood. If the research can be duplicated on humans, the discovery could enhance the usefulness of adult stem cells continuing to make them superior to embryonic stem cells. Cord blood, which is one of the easiest sources from which to obtain stem cells, have the potential to be like embryonic stem cells. “We think cord blood is the next best thing to embryonic stem cells,” David Harris, University of Arizona microbiology professor, said. “These cells are versatile and robust. Neonatal stem cells are fairly equivalent to fetal stem cells, without all the controversy and hindrance.” Harris expects that heart attack and Type 1 diabetes patients will routinely be treated with stem cells within the next five years. Within 10 years, stem-cell applications will include treatments of cancer and viral infections. Arizona is focusing on neonatal and ASCs and excluding ESCs. “We’ve cured almost every single disease there is in mice,” Stuart Williams, University of Arizona professor and chairman of biomedical engineering, said. “Now it's translating it from mice to humans. Fifteen years from now, I foresee patients not needing heart transplants. We’ll replace tissue that has become damaged with healthy tissue.” Williams said he settled on fat cells because they’re a sufficient source for everybody. In a single operation, stem cells are harvested, prepared and reimplanted in a patient. Once extracted, the stem cells are ready within 30 to 90 minutes. The patient’s new organ is undergoing its development right there in the operating room. Researchers at Massachusetts General Hospital have used adult cells from the spleen to regenerate insulin-producing cells and show “permanent reversal of diabetes” in mice. Essentially the spleen cells “retrain” the body’s immune system to stop attacking its own islet cells, and new cells then naturally regenerate from the spleen cells and the body’s own cells, eliminating the need for any further cell transplant. The Harvard team, headed by Dr. Denise Faustman, now has FDA approval for clinical trials in human juvenile diabetes patients. These and other advances promise new approaches to treating diabetes that require no destruction of human embryos, and offer real hope to diabetic patients. A South Korean woman paralyzed for 20 years is now walking again after scientists repaired her damaged spine using stem cells derived from umbilical cord blood. Thirty-seven-year-old Hwang Mi-Soon told the media she considered her ability to walk nothing short of a miracle. “I never dreamed of getting to my feet again,” she said. Ironically this occurred while John Edwards, former Democratic candidate for vice-president, promised that once the federal government funded ESCR Christopher Reeve would rise from his wheel chair. No English-language publication thought that such an incredible breakthrough as allowing a paraplegic to walk again was newsworthy—probably because it involved the politically incorrect kind of stem cell. There is a widening gulf between the promise of ESCs and the reality of therapy from ASCs—those already in our bodies and umbilical cord blood. ESCs get publicity; ASCs get results. Therapeutic progress with adult stem cells will continue to come fast and furious. Just when the public will be allowed to hear about it is another thing entirely. Is it possible that the difficulties of ESCR can be overcome and that ESCs offer unique therapeutic qualities that will never be supplied by ASCs? Most assuredly, but I hope that we will never learn the answer to that question. Scientific progress should not come at the cost of killing fellow human beings. During World War II the Nazi scientists possibly advanced scientific knowledge by their freezing/hypothermia experiments. The object was to discover how to prepare troops for surviving the Russian winters and for pilots to survive after being shot down at sea. Men were placed into ice vats or exposed naked in sub-zero temperatures to see how fast they would die. Some were exposed for a shorter time to test revival methods. Dr. Sigmund Rascher reported the findings of the experiments at a 1942 medical conference entitled “Medical Problems Arising from Sea and Winter.” The experiments may have advanced scientific knowledge but it was at the cost of killing human beings. The prevailing attitude was that those killed in the experiments, Jewish and Russian prisoners, were slated for death anyhow. So, “Why not profit from them?” Using human embryos, very young human persons, for medical experiments or as raw material for cures is essentially identical with the Nazi attitude: “These embryos are going to die anyhow. So why not profit from them?” Now that ASCs have done everything that ESCs promised but failed to deliver, are superior in culture, do not cause tumors and teratomas, have proven their value in an ever-growing list of therapies, do not present rejection problems, are abundant and readily available without dependence on donors, and above all, do not require killing of anyone and so are not burdened with ethical problems, there is simply no excuse for a continuation of ESCR. Unless one is eager to make a contribution to the culture of death. Thanks to ASCs regenerative medicine will be an exciting field for years to come. If ASCs are at a dead end I hope that all my dead ends prove to be equally expansive. (Printed July, 2006) .
St. Mary's Church Pastor & Vicar
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