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Monsignor Brunner Photo  
by Monsignor James C. Brunner
From the Pastor's Desk

Faith Points
  

Killing Fields Revisited

             Twenty-one months ago I wrote an article entitled “New Killing Fields” which concerned cloning human beings for the purpose of destroying them for their stem cells. There have been many new developments since then, at least with adult stem cells, but the debate continues about the need for human cloning to produce the stem cells necessary for regenerative medicine, to make organs useful for others, or to use as raw material for medical experiments. Embryonic stem cells (ESCs) are produced by taking the genetic material from some living human cell and uniting it with an egg whose nucleus has been removed and then through electrical shock inducing it to live as a new embryo, which would be a twin of the person cloned since it would have his identical DNA. Adult stem cells (ASCs) are derived from cord blood, bone marrow, and many other parts of the body.

             Proponents of  ESCs argue that they are more adaptable to turning into different kinds of tissue and offer more promise for research in regenerative medicine than ASCs. Actually research in ASCs is light years ahead of research in ESCs. An explosion of studies of ASCs has established that they can be converted into any kind of tissue.

             Clones are just as human as the rest of the population and should have the same rights. A ninety year old man in a condominium is the continuation of the same person who started life as an embryo. So-called therapeutic cloning which means killing the clone and harvesting its stem cells is scarcely therapeutic for the clone. It is dangerous to define what is human life according to our needs and wants instead of respecting the reality that is there. In the past blacks have been defined as subhuman and so they could be bought and sold like livestock and worked like draught animals. American Indians were viewed as subhuman and almost exterminated. Blacks were used as guinea pigs in the infamous Tuskegee syphilis study for which our government issued an apology. Jews were considered as less than human by Nazis and half of them were executed in death camps. If the reality of human nature can be redefined for someone’s convenience, then you are also subject to being defined as deserving of elimination. Once you validate a redefinition of humanity you cannot then count on the principle that demands respect for all human life. A watchdog that you have shot cannot protect you when you need him.            

 Apart from the immorality of exploiting human beings for the benefit of others use of ESCs in a widespread program of regenerative medicine is totally impractical. Suppose that 100 million people need regenerative therapy for such conditions as diabetes, Parkinson’s, heart disease, cancers, etc. In the case of the cloned sheep Dolly there was one live birth out of 277 cloned embryos. Assume that researchers could produce a successful embryo out of 100 attempts. That would mean that women of child bearing age would have to contribute 10 billion eggs. If the women demanded $1,000 per egg the costs would be astronomical. Add to this the cost of culturing the stem cells and nudging them to form specific kinds of tissue tailor-made for each patient this approach is a non-starter commercially. Realizing the problem the supporters of ESC research suggest several alternatives. (1) Induce stem cells to produce eggs. If this could be done there is no guarantee that they would not have genetic defects. (2) Create animal-human hybrids. In addition to the repulsiveness of this notion the hybrid would contain non-human DNA and could lead to rejection and disease. (3) Take ovaries from late term aborted females. This macabre solution to the egg dearth would put a premium on third trimester abortions of females. Furthermore every animal that has so far been cloned has genetic and physical defects. There is no reason to believe that the same would not be true for human clones.

            Currently there are zero clinical treatments derived from ESCs. Zero, zip, zilch, nic, rien, nichts, niente, nihil, nada. No human being’s health has been improved by ESCs. There have been very few successes in animal models. They have produced to great fanfare cells that “resemble” lung cells, but nothing that can function as lung cells. They have made some patients worse. ESCs injected into Parkinson’s patients made them more frenetic than before. ESCs injected into the skull of a Chinese man developed into bone, hair, and skin rather than brain cells. Cultures are difficult to establish and maintain. There is difficulty in attaining pure cultures. There still remains the problem of immune rejection. ESCs have a high potential for tumor formation and tissue destruction. They are subject to genomic instability. Alan Trounson, Australian ESC expert, is of the opinion that cloning is now unnecessary because there are at least three or four alternatives that are more attractive already.

             By contrast the future of ASCs is very bright. There are so many exciting studies underway and reported that there is not enough space to list them here. ASCs are able to generate virtually all adult tissues. They can multiply indefinitely and thus provide numbers sufficient for clinical treatment. They are a proven success in laboratory culture, in animal models of disease, and in current clinical treatments. They have a unique ability to “home in” on damaged areas. They are not conducive to tumor formation. There are no problems with transplant rejection because they possess the patient’s own DNA. Adult stem cells may become a defense against terror attacks with weapons that cause radiation. Transplantation of one’s own non-irradiated stem cells is as close to a cure for radiation sickness as we have. If we collected and stored our own stem cells this would defend against many of the consequences of exposure to radiation. ASCs may not have to be isolated, cultured, and reinjected into a patient. Stem cells injected with growth factors have already participated in repair of heart and stroke damage. ASCs have cured diabetes in mice; ameliorated Parkinson’s patients, as opposed to the deterioration brought by ESCs; and have removed the need for heart transplants in five Brazilian heart patients.

            It is stupid to pursue a path that is outrageously expensive, shows little promise, and is ethically repugnant. So why pursue it? There may be a scientific hubris which maintains that things that can be done should be. There might be a desire to control evolution by manipulating human nature. Perhaps people want designer babies. Abortionists may object to anything that gives an embryo a status greater than zero because that may suggest that a fetus has value greater than zero. And they would be right.

             Without actually doing the research it is not possible to know whether ESCs will have any benefit. But if ASCs can do better anything that ESCs might be capable of with less danger and expense and without ethical challenge, why would we want to find out? Currently Australia, Norway, Taiwan, Germany and perhaps soon Canada outlaw all human cloning. It is time for our nation to follow suit. Ask your Senators to support the Brownback-Landrieu bill to outlaw all human cloning.

 (Printed November, 2003)

           

 

 

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